The Chicago Manual of Style says, “The more we learn, the less we seem to know.” Anyone else feel this way about spelling, punctuation and grammar?

So here is a question.

I follow the Oxford English Dictionary for spelling but the Chicago Manual of Style for grammar and punctuation.

The first is British and the second American.

Should I be following the Oxford Guide to Style if I use the Oxford English Dictionary? Or is it okay to follow one British and one American as long as I am consistently British in my spelling and consistently American in my punctuation and grammar? Now let me add that I am Canadian, and I get really confused. The borders seem to be disappearing on me.

And this gets me back to the first line, “The more we learn, the less we seem to know.”

Thoughts?

Thanks for reading . . .